By John Brunstein
2 Dec 2015
Segra Biogen is proud to announce the acceptance by Health Canada for our application for a NPN (Natural Product Number) for our first sleep aid product, Blissful Sleep.
Blissful Sleep is made from two medicinal ingredients – hops strobile, and valerian root. Both are certified organic source and our formulation is made from powdered whole material, not an extract. We use no fillers or colouring agents, and the capsules are made from 100% vegetable source, vegetarian-friendly and halal certified cellulose gum. (What’s cellulose gum? It’s basically just the native natural carbohydrates which make up plant cell walls, so it’s a naturally occurring substance in its own right).
Blissful Sleep can be taken 30-60 minutes before you want to go to sleep, and will help you in getting to sleep faster, sleeping longer, and in having better overall sleep quality if you’re suffering from temporary insomnia[1, 2, 3]. The formulation used in Blissful Sleep won’t have an overpowering effect of making you drowsy or groggy (in case you decide you don’t want to sleep, after all!), nor will it leave you feeling groggy the next morning. Studies have demonstrated that hops-valerian combinations such as this have a gradual onset ‘hypnotic’ effect, which promotes sleep in a physiologic fashion more so than the ‘sudden onset’ effect of common synthetic sleep aids such as benzodiazapines.
Further, Blissful Sleep won’t leave you with ‘rebound insomnia’. This can occur with some synthetic sleep aids, where your body effectively habituates to needing them – so you get to where you can’t sleep without them. Clinical trials on hops-valerian compositions have shown that this doesn’t occur even after 28 days continuous use .
“I read it on the Internet!” We’ve all heard that – but just because something’s written down doesn’t make it true. At Segra, we believe in only basing our products and claims for efficacy and safety on good science – and in being transparent about the sources of that science with our customers. In fact we take assessing the quality of our information sources so seriously that we want you the customer to be able to look up each reference and make your own informed opinions. Below is a selection of some of the high-quality, peer-reviewed data supporting our Blissful Sleep formulation and our claims. Each reference is based on studies conducted on formulations very similar in dosage and composition to Blissful Sleep, which ensures that the conclusions are applicable here. References are numbered and where one serves as a source of specific claims made in our text above, we’ve marked the claim by the relevant reference number. Finally, for each reference we provide annotation in the form of a brief summary of the study findings.
1:Morin 2005: Morin, CM., Koetter, U., Bastien, C., Ware, JC., & Wooten, V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005; 28(11): 1465-1471
As the title suggests, this study compared the effectiveness of a hops – Valerian combination (equivalent to 83.8mg hops, 374 mg Valerian; slightly less than one capsule of Blissful Sleep) with a common synthetic sleep aid, diphenhydramine. It was conducted as a report of a multicenter, randomized, placebo-controlled, parallel-group study conducted in 9 sleep disorder centers throughout the United States with a sample size of 184 participants, and meets Segra’s stringent criteria for assessing study quality. The hops-valerian combination was found to be effective, with reduced sleep latency and significant improvement of patient-assessed Quality of Life scoring over controls. Good safety results were observed (no serious adverse events) and no evidence of rebound insomnia was noted.
2:Koetter 2007: Koetter, U, Schrader, E., Kaufeler, R., & Brattstrőm, A. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytother. Res. 2007; 21: 847-851
A good, double-blinded, placebo controlled trial where a hops-Valerian combination (equivalent to 120 mg hops, 500 mg Valerian; again, very similar to the content of a single Blissful Sleep capsule) was examined for efficacy. Good results in reduction of sleep latency (time to fall asleep), and an increase in slow-wave (deep) sleep was observed versus controls. This study also examined the efficacy of valerian alone, and found it much less effective than when combined with hops – in fact, the valerian-only study arm did not show a statistically valid improvement over placebo controls.
3: Salter 2010: Salter, S. & Brownie, S. Treating primary insomnia: the efficacy of valerian and hops. Aus. Fam. Phys. 2010; 39(6): 433-437
This paper isn’t a study in its own right – instead, it’s a collection and scientifically rigorous critical assessment of nearly 400 peer-reviewed publications on the use of hops, valerian and combinations as sleep aids. Four studies on hops-valerian combinations were identified as meeting all criteria for inclusion in this meta-analysis, and the overall conclusion was that the available data clearly support this combination is clinically demonstrated to be effective in improving one or more sleep parameters. Further, the authors conclude that both Hops and Valerian are considered safe when consumed within the recommended dosage ranges (Hops, 83.8mg – 460 mg equivalent; Valerian, 374-500 mg equivalent) and that adverse reactions to these herbs are rare and mild.